Thermo Fisher Scientific Bestrophin Polyclonal Antibody, FITC
FITC로 표지된 Bestrophin 폴리클로날 항체로, Western blot, IHC, ICC/IF, ELISA 등 다양한 응용에 적합합니다. 인간, 영장류, 랫드 반응성이 있으며, 고순도 친화 크로마토그래피 정제 제품입니다. 연구용으로 시각세포 관련 단백질 연구에 유용합니다.
- 카탈로그번호
- BEST1-2-FITC
- 판매단위
- pk
카탈로그
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| Immunocytochemistry (ICC/IF) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
| Immunomicroscopy (IM) | 1:50–1:200 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Mid-region synthetic peptide corresponding to unique amino acid sequences on human Bestrophin 1 protein |
| Conjugate | FITC (Fluorescein) |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 0.5% BSA, 30% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C, store in dark |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The retinal pigment epithelium (RPE) and choroid form a differentiated system of the eye that supports retinal health and function.
Best vitelliform macular dystrophy (Best disease) is an early-onset autosomal dominant condition characterized by the accumulation of lipofuscin-like material within and beneath the RPE, leading to progressive central vision loss.
This material appears as a yellow mass resembling an egg yolk that later darkens and becomes irregular, a process referred to as “scrambling the egg.”
Best disease often results from mutations in the Bestrophin gene, which encodes a protein with four transmembrane domains localized to the basolateral plasma membrane of RPE cells.
Human Bestrophin forms oligomeric chloride channels sensitive to intracellular calcium, and missense mutations can reduce or abolish Bestrophin-mediated membrane current.
The human Bestrophin gene encodes a 585 amino acid protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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