Thermo Fisher Scientific Bestrophin Polyclonal Antibody, Biotin
Bestrophin 단백질을 타깃으로 하는 Biotin 결합 토끼 다클론 항체. Western blot, IHC, ICC, ELISA 등 다양한 응용에 적합. 인간, 영장류, 랫드 반응성. 고순도 친화크로마토그래피 정제 및 안정한 액상 형태 제공.
- 카탈로그번호
- BEST1-2-BIOTIN
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| Immunocytochemistry (ICC/IF) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
| Immunomicroscopy (IM) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Mid-region synthetic peptide corresponding to unique amino acid sequences on human Bestrophin 1 protein |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 0.5% BSA, 30% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The retinal pigment epithelium (RPE) and choroid form a differentiated system that maintains normal retinal health and function.
Best vitelliform macular dystrophy (Best disease) is an early-onset autosomal dominant disorder characterized by accumulation of lipofuscin-like material within and beneath the RPE, leading to progressive central vision loss.
This material appears as a yellow mass resembling an egg yolk that darkens and becomes irregular over time (“scrambling the egg”).
Best disease often results from mutations in the Bestrophin gene, encoding a protein with four transmembrane domains localized to the basolateral plasma membrane of RPE cells.
Human Bestrophin functions as an oligomeric chloride channel sensitive to intracellular calcium.
Missense mutations in the Bestrophin locus can reduce or abolish Bestrophin-mediated membrane currents.
The human Bestrophin gene encodes a 585 amino acid protein.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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