Thermo Fisher Scientific EEA1 Polyclonal Antibody
EEA1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 IHC에 적합하며 Mouse와 Rat 시료에 반응. 합성 펩타이드 기반 면역원 사용, 비결합형 항체로 장기 보관 시 -20°C 권장.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the internal region of rat EEA1 (Early endosome antigen 1) conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- The peptide is homologous in mouse and shares 95% identity with human.
- Specificity: EEA1.
Target Information
Early endosomal antigen 1 (EEA1) is a 162 kDa membrane-bound protein specific to the early endosome, essential for fusion between early endocytic vesicles.
Early endosomes fuse with endocytic vesicles to redistribute extracellular compounds to alternate destinations.
EEA1 contains zinc-finger-like domains in both amino and carboxyl-terminal regions, similar to those found in nucleic acid binding proteins.
The carboxyl-terminal zinc-finger-like domain is conserved among several non-nuclear proteins involved in intracellular trafficking and is an authentic zinc-binding domain critical for intracellular localization.
Membrane association of EEA1 depends on phosphatidyl 3-kinase activity; inhibitors cause EEA1 to dissociate from early endosomes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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