Thermo Fisher Scientific MLH3 Polyclonal Antibody
Rabbit polyclonal antibody targeting human MLH3 protein for immunocytochemistry; high specificity and affinity purified; suitable for DNA mismatch repair research; provided in liquid form with glycerol for stable storage.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human MLH3. Recombinant protein control fragment (Product #RP-107020) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2665076 |
Product Specific Information
Immunogen sequence:
TTGGIQGTLPL TVQKVLASQA CHGAIKFNDG LSLQESCRLI EALSSCQLPF QCAHGRPSML PLADIDHLEQ EKQIKPNLTK LRKMA
- Highest antigen sequence identity to orthologs: mouse 91%, rat 94%
Target Information
This gene is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination.
The protein encoded by this gene functions as a heterodimer with other family members.
Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations have been linked to hereditary nonpolyposis colorectal cancer type 7 (HNPCC7).
Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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