Thermo Fisher Scientific TOPORS Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant Human TOPORS. Recombinant protein control fragment (Product #RP-107024).

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2664915

Product Specific Information

Immunogen sequence: GGATCQIQGVQ TNDDLNNDSD DSSDNCVIVG FVKPLAERTP ELVELSSDSE DLGSYEKMET VKTQEQEQSY SSGDSDVSRC SSPHSVLGKD EQINKGHCDS STRIKSKKEE KRSTSLSSPR NL

Highest antigen sequence identity to the following orthologs - mouse 85%, rat 86%.

Target Information

Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage-induced cell death through IKBKE sumoylation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.