Thermo Fisher Scientific TOPORS Polyclonal Antibody
Human TOPORS 단백질을 인식하는 Rabbit Polyclonal Antibody로, 세포 내 단백질 발현 연구에 적합합니다. ICC/IF에 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. 4°C 단기 보관, -20°C 장기 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human TOPORS. Recombinant protein control fragment (Product #RP-107024) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2664915 |
Product Specific Information
Immunogen sequence:
GGATCQIQGVQ TNDDLNNDSD DSSDNCVIVG FVKPLAERTP ELVELSSDSE DLGSYEKMET VKTQEQEQSY SSGDSDVSRC SSPHSVLGKD EQINKGHCDS STRIKSKKEE KRSTSLSSPR NL
Highest antigen sequence identity to the following orthologs:
- Mouse: 85%
- Rat: 86%
Target Information
Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, proliferation, and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage-induced cell death through IKBKE sumoylation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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