Thermo Fisher Scientific WWTR1 Polyclonal Antibody
TAZ 단백질(WWSTR1)을 검출하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, Western blot에 최적화되어 있습니다. 인간, 생쥐, 랫트 시료에 반응하며, 항원 친화 크로마토그래피로 정제된 액상 항체입니다. PBS 버퍼에 0.02% sodium azide가 포함되어 있습니다.
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Applications
- Western Blot (WB): Tested dilution 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues V(386) E S A L N K S E P FL T W L(400) of the PDZ-binding domain of human TAZ |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long term storage, store at -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2198939 |
Product Specific Information
PA1-4218 detects the TAZ protein in human, mouse, and rat samples.
It has been successfully used in Western blot procedures and detects a ~49 kDa protein representing TAZ in MDCK cells.
The immunogen is a synthetic peptide corresponding to residues V(386) E S A L N K S E P FL T W L(400) of the 49 kDa human TAZ protein.
Target Information
WW domain-containing transcription regulator protein 1 (WWTR1) is a transcriptional coactivator acting downstream in the Hippo signaling pathway.
This pathway regulates organ size and tumor suppression by controlling cell proliferation and apoptosis.
WWTR1 interacts with PAX8 and NKX2-1/TTF1-dependent gene activation, regulates nuclear accumulation of SMADS, and couples them to transcriptional machinery such as the mediator complex.
It also plays a key role in embryonic stem-cell self-renewal and promotes cell proliferation and epithelial-mesenchymal transition.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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