Thermo Fisher Scientific PAR4 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500

Product Specifications

Product Specific Information

• PA1-4217 detects the Par-4 protein in human samples.
• Successfully used in Western blot procedures.
• Immunogen: synthetic peptide corresponding to residues M(1) A T G G Y R(7) C V(334) V G Q L T R(340) of the N- and C-termini of human Par4, separated by a cysteine.

Target Information

This gene encodes a tumor suppressor protein that selectively induces apoptosis in cancer cells through intracellular and extracellular mechanisms.
The intracellular mechanism involves inhibition of pro-survival pathways and activation of Fas-mediated apoptosis, while the extracellular mechanism involves binding of a secreted form of this protein to glucose regulated protein 78 (GRP78) on the cell surface, leading to activation of the extrinsic apoptotic pathway.
This gene is located on the unstable human chromosomal 12q21 region and is often deleted or mutated in different tumors. The encoded protein also plays an important role in the progression of age-related diseases.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.