Thermo Fisher Scientific PAR4 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to residues M(1) A T G G Y R(7) C V(334) V G Q L T R(340) of the N- and C-termini of human Par4. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:PAR4,uniProtId:Q96IZ0-1,ncbiNodeId:9606,antigenRange:1-7|334-340,antigenLength:340,antigenImageFileName:PA1-4217_PAR4_Q96IZ0-1_Rabbit.svg,antigenImageFileNamePDP:PA1-4217_PAR4_Q96IZ0-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2267828

Product Specific Information

PA1-4217 detects the Par-4 protein in human samples.

PA1-4217 has been successfully used in Western blot procedures.

The PA1-4217 immunogen is a synthetic peptide corresponding to residues M(1) A T G G Y R(7) C V(334) V G Q L T R(340) of the N- and C-termini of human Par4, separated by a cysteine.

Target Information

This gene encodes a tumor suppressor protein that selectively induces apoptosis in cancer cells through intracellular and extracellular mechanisms. The intracellular mechanism involves the inhibition of pro-survival pathways and the activation of Fas-mediated apoptosis, while the extracellular mechanism involves the binding of a secreted form of this protein to glucose regulated protein 78 (GRP78) on the cell surface, which leads to activation of the extrinsic apoptotic pathway. This gene is located on the unstable human chromosomal 12q21 region and is often deleted or mutated different tumors. The encoded protein also plays an important role in the progression of age-related diseases.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.