Thermo Fisher Scientific KAISO Polyclonal Antibody
KAISO(ZBTB33) 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western Blot 및 Immunocytochemistry에 적합합니다. 인간 및 생쥐 시료 반응성이 있으며, Affinity chromatography로 정제되었습니다. 1 mg/mL 농도의 액상 형태로 -20°C에서 보관합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ZBTB33 (Accession Q86T24), corresponding to amino acid residues Q106–A156 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2899426 |
Product Specific Information
This antibody detects endogenous levels of total ZBTB33.
Target Information
This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and three C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and formation of repressive chromatin structures in target gene promoters. It may repress target genes of the Wnt signaling pathway or activate transcription of specific targets via recruitment of catenin delta-2 (CTNND2). Interaction with catenin delta-1 (CTNND1) inhibits DNA binding. It also interacts with nuclear import receptor Importin-alpha 2 (karyopherin alpha2), mediating nuclear import. Alternatively spliced transcript variants encoding the same protein have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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