Thermo Fisher Scientific UHRF1 Recombinant Rabbit Monoclonal Antibody (1H2L41)

Applications and Tested Dilution

Product Specifications

Product Specific Information

This antibody is predicted to react with Monkey, Dog, and Rat.

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems clone specific antibody DNA sequences from immunoreactive rabbits, followed by screening to select optimal clones for production.

Advantages include:

• Improved specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulation
• Broader immunoreactivity due to the larger rabbit immune repertoire

Target Information

The UHRF1 gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds specific DNA sequences and recruits histone deacetylases to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle.

It plays a major role in the G1/S transition by regulating topoisomerase IIα and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. Multiple transcript variants encoding different isoforms have been identified for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.