Thermo Fisher Scientific Ly-6G Monoclonal Antibody (1A8-Ly6g), Brilliant Violet 421, eBioscience
마우스 Ly-6G(Gr-1)에 특이적인 단클론 항체로, 호중구 표지를 위한 유세포분석에 적합합니다. Brilliant Violet 421 형광체로 결합되어 405 nm 레이저에서 사용 가능하며, 비특이적 결합 최소화를 위해 Brilliant Stain Buffer 사용을 권장합니다. 연구용 전용 제품입니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Flow Cytometry (Flow) | 1.0 µg/test |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rat / IgG2a, kappa |
| Recommended Isotype Control | Rat IgG2a kappa Isotype Control (eBR2a), Brilliant Violet™ 421, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1A8-Ly6g |
| Conjugate | Brilliant Violet™ 421 |
| Excitation/Emission Max | 406/423 nm |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2925553 |
Available Conjugate Formats
- Alexa Fluor 700
- APC
- APC-eFluor 780
- Biotin
- Brilliant UV 395 / 563 / 661 / 737
- Brilliant Violet 480 / 650 / 786
- eFluor 450
- FITC
- Functional Grade
- PE / PE-Cyanine5 / PE-Cyanine7 / PE-eFluor 610
- PerCP-eFluor 710
- Super Bright 436 / 600 / 702
- Request custom conjugation
Product Specific Information
The monoclonal antibody 1A8-Ly6g reacts with mouse Ly-6G (Gr-1), a 25-kDa GPI protein expressed exclusively by neutrophils. It plays a role in neutrophil infiltration, recruitment, and migration, and associates with β2 integrins CD11a and CD11b.
Unlike the RB6-8C5 antibody, 1A8-Ly6g binds only to Ly-6G on neutrophils and has been used for neutrophil depletion, showing antagonist activity.
Applications Reported: Flow cytometric analysis.
Applications Tested: Tested on mouse bone marrow cells at ≤1.0 µg/test (in 100 µL final volume). Optimal titration is recommended.
Fluorochrome Information:
Brilliant Violet™ 421 (BV421) emits at 423 nm, suitable for cytometers with a 405 nm violet laser. Verify instrument compatibility before use.
When using multiple polymer dye-conjugated antibodies (e.g., Super Bright, Brilliant Violet™, Brilliant UV™), use Super Bright Complete Staining Buffer (SB-4401-42) or Brilliant Stain Buffer™ (00-4409-75) to minimize non-specific interactions.
Excitation: 407 nm
Emission: 423 nm
Laser: Violet Laser
BRILLIANT VIOLET™ is a trademark of Becton, Dickinson and Company, used under license. Powered by Sirigen™.
Target Information
Ly6G (Lymphocyte antigen 6 complex locus G6D) is part of the myeloid differentiation antigen Gr-1 complex with Ly6C.
- Molecular weight: 21–25 kDa
- Expressed by: Myeloid-derived bone marrow cells
- Marker for: Peripheral neutrophils, monocytes, granulocytes
- Function: Involved in granulocyte differentiation and maturation, anti-tumor response, and modulation of local immune responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without authorization.
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