Thermo Fisher Scientific PABPC4 Polyclonal Antibody
Rabbit polyclonal antibody targeting human PABPC4 protein. Validated for WB and ICC/IF applications. High specificity through antigen affinity purification. Supplied in liquid form with PBS/glycerol buffer. Ideal for research on mRNA stability and tran...
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Applications
Western Blot (WB)
- Tested Dilution: 0.04–0.4 µg/mL
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human PABPC4. Recombinant protein control fragment (Product #RP-105047) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.04 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2663234 |
Product Specific Information
Immunogen sequence:
QYMQRVAGMRA LPANAILNQF QPAAGGYFVP AVPQAQGRPP YYTPNQLAQM RPNP
Highest antigen sequence identity to the following orthologs:
- Mouse: 98%
- Rat: 100%
Target Information
Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs.
PABPC4 (inducible PABP) is expressed in activated T cells, with mRNA levels increasing approximately 5-fold upon activation.
It contains four RNA-binding domains and a proline-rich C terminus, primarily localized in the cytoplasm.
PABPC4 may regulate stability of labile mRNA species in activated T cells and is also known as APP1 (activated-platelet protein-1), expressed on thrombin-activated platelets.
It may play roles in protein translation regulation in platelets and megakaryocytes, or stabilization of polyadenylates in platelet dense granules.
Alternatively spliced transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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