Thermo Fisher Scientific PABPC4 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.04–0.4 µg/mL

Immunocytochemistry (ICC/IF)

• Tested Dilution: 0.25–2 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
QYMQRVAGMRA LPANAILNQF QPAAGGYFVP AVPQAQGRPP YYTPNQLAQM RPNP

Highest antigen sequence identity to the following orthologs:

• Mouse: 98%
• Rat: 100%

Target Information

Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs.
PABPC4 (inducible PABP) is expressed in activated T cells, with mRNA levels increasing approximately 5-fold upon activation.
It contains four RNA-binding domains and a proline-rich C terminus, primarily localized in the cytoplasm.
PABPC4 may regulate stability of labile mRNA species in activated T cells and is also known as APP1 (activated-platelet protein-1), expressed on thrombin-activated platelets.
It may play roles in protein translation regulation in platelets and megakaryocytes, or stabilization of polyadenylates in platelet dense granules.
Alternatively spliced transcript variants encoding different isoforms have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.