Thermo Fisher Scientific VRK3 Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:1,000–1:2,500

Immunocytochemistry (ICC/IF)

• Tested Dilution: 0.25–2 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
CPYCGNSLPVE EHVGSQTFVN PHVSSFQGSK RGLNSSFETS PKKVKWSSTV TSPRLSLFSD GDSSESEDTL SS

Highest antigen sequence identity to the following orthologs:

• Mouse: 68%
• Rat: 73%

Target Information

This gene encodes a member of the vaccinia-related kinase family of serine/threonine protein kinases. In both human and mouse, this gene has substitutions at several residues within the ATP binding motifs that in other kinases have been shown to be required for catalysis. In vitro assays indicate the protein lacks phosphorylation activity but likely retains substrate binding capability. This gene is widely expressed in human tissues and its protein localizes to the nucleus. Alternative splicing results in multiple transcripts encoding different isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.