Thermo Fisher Scientific ZEB2 Monoclonal Antibody (OTI4G3), TrueMAB
ZEB2 단백질을 인식하는 Mouse monoclonal 항체로 Western blot에 적합합니다. 인간 시료에 반응하며, 고순도 Affinity chromatography로 정제되었습니다. PBS/BSA/glycerol buffer에 보관되며, 연구용으로만 사용 가능합니다.
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4G3 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–350 of human ZEB2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
ZEB2, initially identified as Smad interacting-protein 1, is a nuclear DNA-binding transcriptional repressor that interacts with activated SMADs. Similar to ZEB1, ZEB2 inhibits E-cadherin transcription and induces epithelial-mesenchymal transition (EMT), a genetic program controlling cell migration during embryonic development and wound healing. ZEB2 also protects cells from DNA damage-induced apoptosis, suggesting a role in tumor progression. It is frequently observed in the cytoplasm of various cancer tissues, indicating regulated localization in normal and tumor contexts. Mutations in this gene are associated with Hirschsprung disease and Mowat-Wilson syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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