Thermo Fisher Scientific p14ARF Polyclonal Antibody
Human p14ARF 단백질을 표적으로 하는 Thermo Fisher Scientific의 rabbit polyclonal antibody. Western blot, ICC/IF, IP에 적합하며 높은 특이성과 감도를 제공. 항원 친화 크로마토그래피로 정제되어 연구용으로 신뢰성 높음.
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Thermo Fisher Scientific p14ARF Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
| Immunoprecipitation (IP) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human CDKN2A/p14ARF |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.02 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2792747 |
Product Specific Information
- Keep as concentrated solution.
- Positive Control: HeLa.
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The INK4a locus on chromosome 9p21 is frequently affected in human tumors. It encodes two structurally distinct tumor suppressor proteins, p16INK4a and the alternative reading frame protein, ARF (p14ARF in human and P19ARF in mouse). These proteins interact with upstream tumor suppressors, retinoblastoma protein and p53, respectively. Each plays a role in cellular senescence, cell cycle control, and tumor suppression. The p14ARF (or P19ARF in mouse) proteins can induce G1 and G2 phase arrest dependent on functional p53. The differing functions of mouse and human ARF proteins may contribute to species-specific tumor susceptibility.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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