Thermo Fisher Scientific PON3 Monoclonal Antibody (OTI1A5), TrueMAB

Applications and Tested Dilution

Product Specifications

Target Information

Paraoxonase-1 (PON1) is a calcium-dependent ester hydrolase associated with apoA-I in HDL. PON1 prevents the oxidation of LDL, thereby reducing the formation of atherogenic oxidised-LDL. Polymorphisms of the human PON1 gene are correlated with coronary artery disease, indicating a genetic association between PON1 and coronary artery disease. PON1 activity is lower in subjects prone to atherosclerosis, such as those with type 1 and type 2 diabetes, familial hypercholesterolemia, and renal disease, suggesting its involvement in atherosclerosis development.
PON2 is a ubiquitously expressed intracellular protein that can protect cells against oxidative damage. PON3 is similar to PON1 in activity but differs in substrate specificity. PON1 and PON3 are implicated in lowering the risk of developing coronary artery disease and atherosclerosis. Human PON3 protein shares the three conserved cysteine residues identified in PON1, suggesting their importance in in vivo activities. PON1-based catalytic scavengers can serve as potential therapeutic agents for organophosphate intoxication.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.