Thermo Fisher Scientific PON3 Monoclonal Antibody (OTI1B12), TrueMAB
Thermo Fisher Scientific의 PON3 단일클론 항체(OTI1B12)는 인간 PON3 단백질을 타겟으로 한 연구용 항체입니다. Western blot과 IHC(P)에서 사용 가능하며, 고순도의 액상 형태로 제공됩니다. 항체는 PBS/BSA/glycerol buffer에 보존되며 -20°C에서 안정적으로 저장됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1B12 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 30–319 of human PON3 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Paraoxonase-1 (PON1) is a calcium-dependent ester hydrolase tightly associated with apoA-I in HDL. PON1 prevents oxidation of LDL, thereby reducing formation of atherogenic oxidised-LDL. Polymorphisms of the human PON1 gene are correlated with coronary artery disease. PON1 activity is lower in subjects prone to atherosclerosis such as in diabetes, familial hypercholesterolemia, and renal disease. PON2 is an intracellular protein that protects cells against oxidative damage. PON3 is similar to PON1 in activity but differs in substrate specificity. Both PON1 and PON3 are implicated in lowering the risk of coronary artery disease and atherosclerosis. Human PON3 protein shares three conserved cysteine residues identified in PON1, suggesting their importance in vivo. PON1-based catalytic scavengers may offer safe and effective protection against organophosphate intoxication.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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