Thermo Fisher Scientific Caspase 7 p11 Polyclonal Antibody

Thermo Fisher Scientific Caspase 7 p11 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Recommended positive controls: 293T, A431, HeLa, HepG2, Jurkat (including Jurkat treated with 10 µM etoposide for 24 hr)
• Predicted reactivity: Mouse (91%), Rat (91%), Zebrafish (83%), Xenopus laevis (82%)
• Store product as a concentrated solution and centrifuge briefly prior to opening the vial

Target Information

This gene encodes a protein belonging to the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution phase of cell apoptosis. Caspases exist as inactive proenzymes that undergo proteolytic processing at conserved aspartic residues to produce large and small subunits, which dimerize to form the active enzyme. The precursor of this caspase is cleaved by caspase 3 and 10, becoming activated upon cell death stimuli to induce apoptosis. Alternative splicing results in four transcript variants encoding three distinct isoforms.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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