Thermo Fisher Scientific Caspase 7 p11 Polyclonal Antibody
Caspase 7 p11 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, IP에 사용 가능. 인간에 반응하며 항원 친화 크로마토그래피로 정제됨. 세포사멸 연구 및 Caspase 활성 분석에 적합. 연구용으로만 사용.
- 카탈로그번호
- PA532146
- 판매단위
- pk
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Thermo Fisher Scientific Caspase 7 p11 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:1,000 |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 158–303 of Human Caspase 7 p11 subunit |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.93 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2549619 |
Product Specific Information
- Recommended positive controls: 293T, A431, HeLa, HepG2, Jurkat (including Jurkat treated with 10 µM etoposide for 24 hr)
- Predicted reactivity: Mouse (91%), Rat (91%), Zebrafish (83%), Xenopus laevis (82%)
- Store product as a concentrated solution and centrifuge briefly prior to opening the vial
Target Information
This gene encodes a protein belonging to the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution phase of cell apoptosis. Caspases exist as inactive proenzymes that undergo proteolytic processing at conserved aspartic residues to produce large and small subunits, which dimerize to form the active enzyme. The precursor of this caspase is cleaved by caspase 3 and 10, becoming activated upon cell death stimuli to induce apoptosis. Alternative splicing results in four transcript variants encoding three distinct isoforms.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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