Thermo Fisher Scientific CD137 Polyclonal Antibody
CD137(TNFRSF9) 단백질을 인식하는 토끼 폴리클로날 항체로, Western blot과 면역세포염색(ICC/IF)에 적합합니다. 인체 및 랫트 반응성이 있으며, 친화 크로마토그래피로 정제되었습니다. 액상 형태로 PBS(50% 글리세롤) 버퍼에 보관되며, 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human TNFRSF9 (Accession Q07011), corresponding to amino acid residues D87–T137 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2854163 |
Product Specific Information
Antibody detects endogenous levels of total TNFRSF9.
Target Information
CD137, also known as TNFRSF9 or 4-1BB, is an inducible costimulatory molecule expressed mainly on activated T cells. Its ligand, 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells. CD137 signaling supports the survival and clonal expansion of activated and CD8+ memory T cells, while regulating myelopoiesis and dendritic cell development. Activation of CD137 induces cytokine release that modulates peripheral monocyte survival. Soluble forms of CD137 may act as negative regulators in certain immune responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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