Thermo Fisher Scientific Phospho-GluR2 (Tyr876) Polyclonal Antibody

Applications and Tested Dilution

Species Reactivity

Human, Mouse, Rat

Host / Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human GRIA2 (Accession P42262), corresponding to amino acid residues around phosphorylated Tyr876.

Conjugate

Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Sequential chromatography

Storage Buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage Conditions

-20°C

Shipping Conditions

Wet ice

RRID

AB_2817576

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Product Specific Information

Antibody detects endogenous levels of GluR2 only when phosphorylated at Tyr876.

Target Information

The ion channels activated by glutamate are typically divided into two classes:

• NMDA receptors (NMDAR), sensitive to N-methyl-D-aspartate
• AMPA receptors (AMPAR), activated by alpha-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid

AMPARs are composed of four distinct Glutamate Receptor Subunits (GluR1–4) and play key roles in excitatory neurotransmission in the brain. The GluR2 subunit is particularly important in forms of synaptic plasticity such as long-term depression (LTD).

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For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.