Thermo Fisher Scientific TCP-1 zeta Polyclonal Antibody
Rabbit polyclonal antibody targeting TCP-1 zeta, reactive with human, mouse, and rat. Suitable for WB and IHC applications. Detects endogenous 60 kDa protein. Purified by antigen affinity chromatography and supplied as liquid form in PBS with glycerol....
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 216–261 of human TCP-1 zeta |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553898 |
Product Specific Information
This antibody detects endogenous TCP-1 zeta protein at a molecular weight of approximately 60 kDa.
Purity is greater than 95% by SDS-PAGE.
Target Information
TCP-1 (t complex polypeptide 1) is a subunit of the heterooligomeric complex CCT (chaperonin containing TCP-1) found in the eukaryotic cytosol. The CCT complex consists of eight distinct subunits: TCP-1 alpha, beta, gamma, delta, epsilon, zeta, eta, and theta, each encoded by separate genes.
Two zeta subunits have been described: TCP-1 zeta (also known as TCP-1 zeta1) and TCP-1 zeta2. These subunits have independent roles in folding actin and tubulin substrates. TCP-1 was initially identified in mice for its relevance to tail-less and embryonic lethal phenotypes. Homologous sequences have been found in other species, and yeast TCP-1 encodes a molecular chaperone for actin and tubulin. In mammalian and yeast cells, TCP-1 plays a crucial role in folding cytosolic proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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