Thermo Fisher Scientific ATF7 Polyclonal Antibody
ATF7 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, Western blot에 적합합니다. 사람 및 생쥐 시료 반응성이 있으며, 항원 친화 크로마토그래피로 정제되었습니다. 세포 신호전달 연구용으로 사용됩니다.
- 카탈로그번호
- PA549790
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific ATF7 Polyclonal Antibody
Applications
- Western Blot (WB): 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from internal of human ATF7 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2635243 |
Product Specific Information
The antibody detects endogenous levels of total ATF7 protein.
Target Information
ATF7 plays important roles in early cell signaling. It binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), found in many viral and cellular promoters. It activates the NF-ELAM1/delta-A site of the E-selectin promoter. Although it has no intrinsic transcriptional activity, ATF7 activates transcription upon forming heterodimers with JUN or FOS. It can also bind TRE promoter sequences when heterodimerized with JUN family members. Isoform 4 (ATF-A0) acts as a dominant repressor of the E-selectin/NF-ELAM1/delta-A promoter. Isoform 5 (ATF-4) acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities, potentially by sequestering the Thr-53 phosphorylating kinase in the cytoplasm, preventing activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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