Thermo Fisher Scientific DKC1 Polyclonal Antibody
DKC1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, WB, IHC, ICC, ELISA에 적합합니다. Human 및 Mouse 시료에 반응하며, 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
| Immunocytochemistry (ICC/IF) | 1:50–1:100 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–180 of human DKC1 (NP_0013541) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.19 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805178 |
Product Specific Information
Immunogen sequence:
MADAEVIILP KKHKKKKERK SLPEEDVAEI QHAEEFLIKP ESKVAKLDTS QWPLLLKNFD KLNVRTTHYT PLACGSNPLK REIGDYIRTG FINLDKPSNP SSHEVVAWIR RILRVEKTGH SGTLDPKVTG CLIVCIERAT RLVKSQQSAG KEYVGIVRLH NAIEGGTQLS RALETLTGAL
Positive Samples: HeLa, 22Rv1, HepG2, MCF7, K-562
Cellular Location: Cajal body, Cytoplasm, Nucleus, nucleolus
Target Information
This gene is a member of the H/ACA snoRNPs gene family involved in rRNA processing and modification. The encoded protein, along with NOLA1–3, localizes to nucleoli and coiled bodies in the nucleus and is essential for 18S rRNA production and pseudouridylation. It is also a component of the telomerase complex and homologous to yeast Cbf5p and Drosophila Nop60B. Mutations in this gene cause X-linked dyskeratosis congenita and Hoyeraal-Hreidarsson syndrome. Two transcript variants encoding different isoforms have been identified.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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