Thermo Fisher Scientific CHCHD6 Polyclonal Antibody
Rabbit 폴리클로날 항체로 Human CHCHD6 단백질을 특이적으로 인식합니다. Western blot 및 ELISA에 적합하며 미토콘드리아 단백질 연구에 활용됩니다. 고순도 Affinity Chromatography 정제, 3.26 mg/mL 농도의 액상 형태로 제공됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–235 of human CHCHD6 (NP_1157191) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 3.26 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805177 |
Product Specific Information
Immunogen sequence:
MGSTESSEGR RVSFGVDEEE RVRVLQGVRL SENVVNRMKE PSSPPPAPTS STFGLQDGNL RAPHKESTLP RSGSSGGQQP SGMKEGVKRY EQEHAAIQDK LFQVAKRERE AATKHSKASL PTGEGSISHE EQKSVRLARE LESREAELRR RDTFYKEQLE RIERKNAEMY KLSSEQFHEA ASKMESTIKP RRVEPVCSGL QAQILHCYRD RPHEVLLCSD LVKAYQRCVS AAHKG
Positive Samples: A-549, HeLa
Cellular Location: Lipid-anchor, Mitochondrion, Mitochondrion inner membrane
Target Information
CHCHD6 is a member of a family of proteins containing a conserved (coiled coil 1)-(helix 1)-(coiled coil 2)-(helix 2) domain. It forms a complex with mitochondrial proteins such as mitofilin, SAM50, metaxins 1 and 2, and CHCHD3. CHCHD6 knockdown leads to severe defects in mitochondrial cristae morphology, reduced cell growth, ATP production, and oxygen consumption. It also decreases mitofilin protein levels, suggesting coordinated regulation between CHCHD6 and mitofilin. CHCHD6 knockdown in human cancer cells increases sensitivity to genotoxic anticancer drugs, indicating its potential as a therapeutic anti-tumor target.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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