Thermo Fisher Scientific AVEN Polyclonal Antibody
인간 및 랫트 반응성을 가진 Rabbit Polyclonal AVEN 항체로, Western blot과 ELISA에 사용 가능. 재조합 단백질(AA 203–362)을 면역원으로 사용하며, 액상 형태로 0.91 mg/mL 농도. 세포 내막계 및 주변막 단백질 검출에 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 203–362 of human AVEN (NP_0651041) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.91 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805176 |
Product Specific Information
Immunogen sequence:
VQGTVPLEVP QVKPKRTDDG KGLGMQLKGP LGPGGRGPIF ELKSVAAGCP VLLGKDNPSP GPSRDSQKPT SPLQSAGDHL EEELDLLLNL DAPIKEGDNI LPDQTSQDLK SKEDGEVVQE EEVCAKPSVT EEKNMEPEQP STSKNVTEEE LEDWLDSMIS
Positive Samples:
22RV1, HT-29, LO2, HeLa
Cellular Location:
Endomembrane system, Peripheral membrane protein
Target Information
Apoptosis plays a major role in organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been linked to diseases such as cancer.
Aven is a protein that blocks apoptosis induced by Apaf-1 and caspase-9. It binds to Bcl-xL (antiapoptotic Bcl-2 family) and Apaf-1, possibly interfering with Apaf-1 self-association, thereby impeding caspase activation.
Higher Aven mRNA levels are observed in acute leukemia patients, suggesting potential prognostic relevance.
⚠ WARNING: This product can expose you to chemicals including mercury, known to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only.
Not for use in diagnostic procedures or resale without authorization.
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