Thermo Fisher Scientific Chk1 Polyclonal Antibody
Rabbit polyclonal antibody targeting human Chk1, validated for IHC and IHC (Paraffin) applications. Recognizes conserved region (aa 250–300) of Checkpoint Kinase 1. Supplied as liquid, unconjugated, purified by antigen affinity chromatography, stored a...
- 카탈로그번호
- IHC00004x (2개 옵션)
- 판매단위
- pk
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Applications
Immunohistochemistry (IHC)
- Tested Dilution: 1:100–1:500
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 250–300 of human Checkpoint Kinase 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.10 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, predicted to react with Dog, Pig, Panda, Orangutan, Monkey, Gorilla, Chimpanzee, Northern white-cheeked gibbon, and Small-eared galago
Target Information
CHEK1 (CHK1) is a serine/threonine protein kinase involved in preventing replication when DNA integrity is compromised. It acts as a key mediator in the DNA damage-induced checkpoint network and ensures genomic integrity under genotoxic stress. Inhibition of CHK1 can lead to mitotic catastrophe and apoptosis in p53-deficient cancer cells, making CHK1 an attractive therapeutic target for cancer treatment.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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