Thermo Fisher Scientific CYP17A1 Polyclonal Antibody
CYP17A1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 ELISA에 적합합니다. Human, Mouse, Rat 시료에 반응하며, Affinity Chromatography로 정제되었습니다. PBS/glycerol buffer에 보관되며 연구용으로 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 209–508 of human CYP17A1 (NP_000093.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.49 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2913809 |
Product Specific Information
- Positive test controls: Rat testis
- Subcellular location: Membrane
Immunogen sequence:
LSKDSLVDLV PWLKIFPNKT LEKLKSHVKI RNDLLNKILE NYKEKFRSDS ITNMLDTLMQ AKMNSDNGNA GPDQDSELLS DNHILTTIGD IFGAGVETTT SVVKWTLAFL LHNPQVKKKL YEEIDQNVGF SRTPTISDRN RLLLLEATIR EVLRLRPVAP MLIPHKANVD SSIGEFAVDK GTEVIINLWA LHHNEKEWHQ PDQFMPERFL NPAGTQLISP SVSYLPFGAG PRSCIGEILA RQELFLIMAW LLQRFDLEVP DDGQLPSLEG IPKVVFLIDS FKVKIKVRQA WREAQAEGST
Target Information
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids. This protein localizes to the endoplasmic reticulum and has both 17α-hydroxylase and 17,20-lyase activities. It is a key enzyme in the steroidogenic pathway producing progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Mutations in this gene are associated with isolated steroid-17α-hydroxylase deficiency, 17α-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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