Thermo Fisher Scientific PSME2 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Positive test controls: U-251MG, Mouse thymus, Mouse lung, Mouse kidney
• Immunogen sequence:
  MAKPCGVRLS GEARKQVEVF RQNLFQEAEE FLYRFLPQKI IYLNQLLQED SLNVADLTSL RAPLDIPIPD PPPKDDEMET DKQEKKEVHK CGFLPGNEKV LSLLALVKPE VWTLKEKCIL VITWIQHLIP KIEDGNDFGV AIQEKVLERV NAVKTKVEAF QTTISKYFSE RGDAVAKASK ETHVMDYRAL VHERDEAAYG ELRAMVLDLR AFYAELYHII SSNLEKIVNP KGEEKPSMY

Target Information

Proteolytic degradation is essential for maintaining proper levels of short-lived and regulatory proteins involved in metabolism, stress response, antigen presentation, receptor modulation, cell cycle regulation, transcription, and signaling. The ubiquitin-proteasome pathway is the primary mechanism for protein degradation in eukaryotic cytosol and nucleus, while the vacuolar pathway handles others through endosomes, lysosomes, and the endoplasmic reticulum.

The 26S proteasome is an ATP-dependent, multisubunit (≈31) molecular complex (~2.5 MDa) consisting of a 20S proteolytic core and 19S regulatory subunits. The 19S subunit recognizes ubiquitinated proteins, unfolding and translocating them into the 20S core for degradation. Defects in this pathway are linked to genetic diseases such as cystic fibrosis, Angelman’s syndrome, and Liddle syndrome.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.