Thermo Fisher Scientific CCL19 Polyclonal Antibody
CCL19 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, ICC/IF, ELISA 등 다양한 응용에 적합합니다. Human, Mouse, Rat 시료에 반응하며, 고순도의 Affinity Chromatography 정제 항체입니다. PBS/glycerol buffer에 보존되어 안정적입니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:100 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 22–95 of human CCL19 (NP_006265.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.22 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2854899 |
Product Specific Information
Immunogen sequence:
GTNDAEDCCL SVTQKPIPGY IVRNFHYLLI KDGCRVPAVV FTTLRGRQLC APPDQPWVER IIQRLQRTSA KMKR
Target Information
CCL19, also known as MIP-3 beta (Macrophage Inflammatory Protein 3 beta), is a member of the CC-subfamily of chemokines. It is most closely related to CCL21, sharing 32% amino acid sequence homology. CCL19 and CCL21 are expressed mainly by stromal cells in the T cell-rich zones of lymph nodes and are critical mediators of the homeostatic trafficking of naive T cells and activated dendritic cells into secondary lymphoid organs. They also play roles in T cell priming, activation, and lymphocyte recruitment to inflamed tissues. Both signal via the G protein-coupled receptor CCR7, expressed on T cells and mature dendritic cells. Although both CCL19 and CCL21 bind CCR7 with similar affinity, only CCL19 binding leads to receptor desensitization and internalization.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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