Thermo Fisher Scientific CBX4 Polyclonal Antibody
Thermo Fisher Scientific의 CBX4 폴리클로날 항체는 인간 및 마우스 시료에서 CBX4 단백질 검출에 적합합니다. Western blot과 ELISA에 사용 가능하며, 고순도 친화 크로마토그래피 정제 제품입니다. 액상 형태로 안정적이며 -20°C에서 보관합니다.
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Thermo Fisher Scientific CBX4 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1 µg/mL |
Publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 401–560 of human CBX4 (NP_003646.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.69 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2854893 |
Product Specific Information
Immunogen sequence:
AVGLNLSHVR KRCLSETHGE REPCKKRLTA RSISTPTCLG GSPAAERPAD LPPAAALPQP EVILLDSDLD EPIDLRCVKT RSEAGEPPSS LQVKPETPAS AAVAVAAAAA PTTTAEKPPA EAQDEPAESL SEFKPFFGNI IITDVTANCL TVTFKEYVTV
Target Information
Polycomb group (PcG) proteins are chromatin-associated proteins important for embryonic and adult stem cell self-renewal and maintenance. At least two distinct human PcG complexes have been identified.
Polycomb repressive complex I (PRC1) contains CBX4/Pc2, HPH1, and RING domain-containing proteins (RING1, RING2, and BMI1).
CBX4 (Chromobox protein homolog 4 or PC2) functions as a transcriptional suppressor and acts as an E3 SUMO-protein ligase facilitating SUMO1 conjugation.
Depletion of CBX4 results in decreased cellular resistance to ionizing radiation and is directly involved in the cellular response to DNA damage.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: PA5-109482_CBX4_O00257-1_Rabbit.svg, PA5-109482_CBX4_O00257-1_Rabbit_PDP.jpeg)
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