Thermo Fisher Scientific Arg3.1 Polyclonal Antibody
Arg3.1(ARC) 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC에 적합합니다. 인간 시료에 반응하며, 시냅스 가소성 연구 및 신경세포 간 RNA 전달 메커니즘 연구에 유용합니다. 동결건조 형태로 제공되며, 장기 보관 시 -20°C에서 안정적입니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous (PubMed) | - | View 2 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide from the C-terminal region of human Arg3.1 (ARC) conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C (short term). For long-term storage, store at -20°C. Avoid freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 150 µL of MQ water.
- Centrifuge to remove any insoluble material.
- Specificity: Arg3.1 / ARC.
Target Information
Arg3.1 (ARC) is a master regulator of synaptic plasticity that self-assembles into virion-like capsids encapsulating RNAs for intercellular transfer in the nervous system. ARC is released from neurons via extracellular vesicles, transferring ARC mRNA into new target cells where it undergoes activity-dependent translation.
ARC capsids are endocytosed and can deliver ARC mRNA into neuronal cytoplasm. It is essential for protein synthesis-dependent long-term potentiation (LTP), long-term depression (LTD), and long-term memory formation. ARC regulates synaptic plasticity by promoting endocytosis of AMPA receptors (AMPARs), maintaining neuronal homeostasis through synaptic scaling.
Additionally, ARC mediates synapse elimination in the developing cerebellum, accumulates at weaker synapses to prevent undesired enhancement, and may facilitate elimination of synaptic material. ARC is also implicated in visual cortex plasticity and amyloid-beta processing via PSEN1 interaction. Beyond neuronal roles, ARC is expressed in skin-migratory dendritic cells, regulating fast migration and T-cell activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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