Thermo Fisher Scientific GUK1 Polyclonal Antibody
Thermo Fisher Scientific의 GUK1 Polyclonal Antibody는 인간 Guanylate kinase 단백질을 표적하는 rabbit IgG 항체로, Western blot 및 IHC(P) 실험에 적합합니다. 고순도 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보관됩니다. 연구용으로만 사용 가능합니다.
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 1–197 of Human Guanylate kinase |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 40% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2545008 |
Product Specific Information
- Recommended positive controls: 293T
- Predicted reactivity: Mouse (87%), Rat (87%), Rhesus Monkey (97%), Bovine (90%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Guanylate kinase (GK) catalyzes the ATP-dependent phosphorylation of GMP into GDP and is essential for recycling GMP and indirectly cGMP. GK is a highly conserved monomeric protein (~200 amino acids) found across prokaryotes, lower eukaryotes, and vertebrates.
It shares structural similarity with Vaccinia virus protein A57R (SalG2R). Proteins containing DHR, SH3, and GK-like domains are collectively termed MAGUKs (membrane-associated guanylate kinase homologs), including:
- Drosophila lethal(1)discs large-1 (dlg1)
- Mammalian Zo-1
- Synaptic proteins (SAP90/PSD-95, CHAPSYN-110/PSD-93, SAP97/DLG1, SAP102)
- Vertebrate p55
- C. elegans lin-2
- Rat protein CASK
- Human DLG2, DLG3
GK contains an ATP-binding site (P-loop) in the N-terminal section, which is not conserved in GK-like domains of MAGUKs but retains residues involved in MP binding.
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: PA5-27532_GUK1_Q16774-1_Rabbit.svg, PA5-27532_GUK1_Q16774-1_Rabbit_PDP.jpeg)
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