Thermo Fisher Scientific CD16/CD32 Recombinant Rat Monoclonal Antibody (2.4G2)
마우스 FcγIII 및 FcγII 수용체의 결합을 억제하는 재조합 랫트 단클론 항체. IHC, ICC/IF, Flow Cytometry, IP, Inhibition Assay에 사용 가능. Protein A 정제, 1 mg/mL 농도, PBS 버퍼에 ProClin 300 포함. 단기 4°C, 장기 -20°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (IHC) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| Flow Cytometry (Flow) | Assay-dependent |
| Immunoprecipitation (IP) | Assay-dependent |
| Inhibition Assays (IA) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rat / IgG2b, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 2.4G2 |
| Immunogen | Mouse BALB/c Macrophage J774 Cell Line |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
Product Specific Information
This antibody binds to an epitope on the extracellular domains of the mouse FcGammaIII and FcGammaII, thereby inhibiting their ability to bind antibodies via their Fc region. It also binds the FcGammaI receptor (CD64) via its Fc domain.
Target Information
CD16 is a 50–65 kDa cell surface molecule existing in two forms: a transmembranous form expressed by natural killer (NK) cells and some T cells, and a phosphatidylinositol-linked form expressed by granulocytes. CD16 is a low-affinity receptor for IgG (FcR III) and mediates antibody-dependent cell-mediated cytotoxicity (ADCC) by NK cells.
CD32 is a 40 kDa glycoprotein acting as a low-affinity receptor for IgG (FcγRII), mediating endocytosis, secretion activation, cytotoxicity, and immunomodulation. It is expressed by B cells, monocytes, granulocytes, and platelets, and is involved in phagocytosis of immune complexes and regulation of antibody production by B cells. Variants of the CD32 gene may increase susceptibility to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms of CD32 have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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