Thermo Fisher Scientific Phospho-GluR1 (Ser863) Polyclonal Antibody
Phospho-GluR1 (Ser863) 폴리클로날 항체로, 인산화된 GluR1 단백질의 Ser863 잔기를 특이적으로 검출. Western blot, IHC, ICC 등 다양한 응용 가능. 인간, 생쥐, 랫트 반응성. 고순도 정제, -20°C 보관.
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Thermo Fisher Scientific Phospho-GluR1 (Ser863) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | - |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human GRIA1 (Accession P42261), corresponding to amino acid residues around phosphorylated Ser863 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816369 |
Product Specific Information
Antibody detects endogenous levels of GluR1 only when phosphorylated at Serine 863.
Target Information
GluR1 (glutamate receptor 1) is an ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of L-glutamate induces a conformational change that opens the cation channel, converting the chemical signal to an electrical impulse. The receptor desensitizes rapidly and enters a transient inactive state characterized by a bound agonist. In the presence of CACNG4, CACNG7, or CACNG8, GluR1 shows resensitization, characterized by delayed current flux upon continued glutamate application.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지: PA5-104896_GluR1_P42261-1_Rabbit.svg, PA5-104896_GluR1_P42261-1_Rabbit_PDP.jpeg)
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