Thermo Fisher Scientific Phospho-STAT5 alpha (Ser780) Polyclonal Antibody
STAT5A의 Ser780 인산화 상태를 특이적으로 검출하는 rabbit polyclonal antibody. Western blot, IHC, ICC/IF, IP 등 다양한 응용에 적합. Human, Mouse, Rat 반응성. 고순도 액상 항체로 -20°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human STAT5A (Accession P42229), corresponding to amino acid residues around phosphorylated Ser780. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816367 |
Product Specific Information
This antibody detects endogenous levels of STAT5A only when phosphorylated at Serine 780.
Target Information
STAT5 alpha is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by receptor-associated kinases, forming homo- or heterodimers that translocate to the cell nucleus to act as transcription activators. STAT5 alpha mediates responses to ligands such as IL-2, IL-3, IL-7, GM-CSF, erythropoietin, thrombopoietin, and various growth hormones. Activation of STAT5 alpha, particularly in myeloma and lymphoma with TEL/JAK2 fusion, is independent of cell stimulus and essential for tumorigenesis. The mouse STAT5 alpha induces BCL2L1/BCL-X(L) expression, indicating an anti-apoptotic role. STAT5 alpha and STAT5 beta share 96% sequence similarity and are co-expressed in most tissues, with differential expression in muscle and mammary tissues. STAT5 alpha is critically involved in reproduction, lactation, immune function, and somatic growth.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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