Thermo Fisher Scientific DUSP22 Polyclonal Antibody
Human DUSP22 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며 PBS 기반 완충액에 1% BSA와 20% glycerol이 포함되어 있습니다. HCT116 세포주에서 양성 대조로 권장됩니다.
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Applications and Tested Dilution
- Western Blot (WB): 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 1–184 of Human DUSP22 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.83 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 1% BSA, 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2546903 |
Product Specific Information
- Recommended positive control: HCT116
- Predicted reactivity: Mouse (93%), Rat (91%), Rhesus Monkey (98%), Chimpanzee (100%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Mitogen-activated protein (MAP) kinases are a large class of proteins involved in signal transduction pathways that are activated by a range of stimuli and mediate various physiological and pathological cellular changes.
Dual specificity phosphatases (DSPs) are a subclass of the protein tyrosine phosphatase (PTP) superfamily, selective for dephosphorylating critical phosphothreonine and phosphotyrosine residues within MAP kinases.
DSP gene expression is induced by growth factors or cellular stress, negatively regulating MAP kinase superfamily members including MAPK/ERK, SAPK/JNK, and p38.
DUSP22 dephosphorylates ERK2 MAP kinase and JNK. DUSP22 shows highest expression in thymus and is also detectable in monocytes and lymphocytes.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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