Thermo Fisher Scientific DUSP1 Monoclonal Antibody (OTI5A8), TrueMAB
인간 DUSP1 단백질을 표적으로 하는 Mouse IgG1 단일클론 항체입니다. Western Blot에 적합하며, 고순도 친화 크로마토그래피로 정제되었습니다. PBS/BSA/glycerol 완충액에 보관되며 연구용으로만 사용됩니다.
- 카탈로그번호
- TA812681
- 판매단위
- pk
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Thermo Fisher Scientific DUSP1 Monoclonal Antibody (OTI5A8), TrueMAB
Applications
- Western Blot (WB)
Tested Dilution
- 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5A8 |
| Immunogen | Full length human recombinant protein of human DUSP1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It encodes a protein with structural features similar to non-receptor-type protein-tyrosine phosphatase family members and shows significant amino acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the vaccinia virus late gene H1. The bacterially expressed and purified DUSP1 protein exhibits intrinsic phosphatase activity, specifically inactivating MAP kinase in vitro by dephosphorylating both phosphothreonine and phosphotyrosine residues. It also suppresses MAP kinase activation by oncogenic Ras in Xenopus oocyte extracts. Therefore, DUSP1 is considered important in the human cellular response to environmental stress and in the negative regulation of cellular proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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