Thermo Fisher Scientific DUSP1 Monoclonal Antibody (OTI8A4), TrueMAB
DUSP1 단백질을 인식하는 Mouse monoclonal antibody로 Western blot에 적합합니다. Human 시료에 반응하며, 정제된 액상 형태로 제공됩니다. -20°C에서 보관하며, 연구용으로만 사용 가능합니다.
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Applications
- Western Blot (WB): 1:500 희석 비율로 테스트됨
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI8A4 |
| Immunogen | Full length human recombinant protein of human DUSP1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative or heat stress and growth factors. It encodes a protein similar to non-receptor-type protein-tyrosine phosphatases and shows sequence similarity to a Tyr/Ser-protein phosphatase encoded by the vaccinia virus H1 gene. DUSP1 protein exhibits intrinsic phosphatase activity, specifically inactivating mitogen-activated protein (MAP) kinase by dephosphorylating both phosphothreonine and phosphotyrosine residues. It also suppresses MAP kinase activation by oncogenic ras in Xenopus oocyte extracts. Therefore, DUSP1 may play an important role in cellular stress response and negative regulation of cell proliferation.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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