Thermo Fisher Scientific Phospho-MKNK2 (Thr249) Polyclonal Antibody
MKNK2 단백질의 Thr249 인산화 형태를 특이적으로 인식하는 폴리클로날 항체입니다. Western blot, IHC, ICC/IF 등 다양한 응용에 적합하며, 인간, 마우스, 랫트에 반응합니다. 고순도 정제 및 안정한 액상 형태로 제공되어 연구 신뢰성을 높입니다.
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Thermo Fisher Scientific Phospho-MKNK2 (Thr249) Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 | - |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 | - |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human MKNK2 (Accession Q9HBH9), corresponding to amino acid residues around phosphorylated Thr249. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817301 |
Product Specific Information
Antibody detects endogenous levels of MKNK2 only when phosphorylated at Thr249.
Target Information
The MAP kinase-interacting kinases (MKNK1 and MKNK2) are activated by MAP kinases and regulate protein synthesis through phosphorylation of eIF4E on Ser209. They may contribute to tumorigenesis. Overexpression of Mnk2 increases phosphorylation of endogenous eIF-4E, indicating its role as an eIF-4E kinase in vivo. Mnk2 may also play a role in responses to environmental stress and cytokines. Expression of active MNK1 and MNK2 mutants in 293 cells reduces cap-dependent translation relative to cap-independent translation. Human Mnk2 shows high homology to murine Mnk2 (94%) and human Mnk1 (71%). In vitro studies demonstrate that Mnk2 is a better substrate for Erk2, p38MAPKα, and p38MAPKβ compared to Mnk1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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