Thermo Fisher Scientific Phospho-MEK5 (Ser311) Polyclonal Antibody
MEK5 단백질의 Ser311 위치에서 인산화된 형태를 특이적으로 인식하는 폴리클로날 항체입니다. Western blot 및 IHC(P) 실험에 적합하며, 인간, 마우스, 랫트 시료에 반응합니다. 고순도 정제된 액상 형태로 제공되며, 연구용으로만 사용 가능합니다.
- 카탈로그번호
- PA5105900
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human MAP2K5 (Accession Q13163), corresponding to amino acid residues around phosphorylated Ser311. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2817299 |
Product Specific Information
Antibody detects endogenous levels of MEK5 only when phosphorylated at Ser311.
Target Information
MAP2K5 (MEK5) is a serine/threonine kinase belonging to the MAP kinase family, which specifically interacts with and activates MAPK7/ERK5. MAP2K5 can be phosphorylated and activated by MAP3K3/MEKK3 and atypical protein kinase C isoforms (aPKCs). This signaling cascade is involved in growth factor–stimulated cell proliferation and muscle cell differentiation. The rs3743354 polymorphism in the MAP2K5 promoter may affect colorectal cancer (CRC) risk.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지: PA5-105900_MEK5_Q13163-1_Rabbit.svg, PA5-105900_MEK5_Q13163-1_Rabbit_PDP.jpeg)
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