Thermo Fisher Scientific Thymidylate Synthase Monoclonal Antibody (TYMS, 1884)
Thymidylate Synthase 단백질을 표적하는 Mouse monoclonal antibody로 다양한 응용(WB, IHC, ICC, Flow Cytometry)에 적합. Recombinant human TS fragment(aa 60-174)을 면역원으로 사용하며, 200 µg/mL 농도의 액상 형태로 제공. 암 연구 및 항암제 반응 분석에 유용.
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- 7298-MSM4-P0
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2c, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | TYMS, 1884 |
| Immunogen | Recombinant human thymidylate synthase protein fragment (around aa 60–174) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Immunohistochemistry (PFA fixed): Incubate antibody for 30 minutes at room temperature.
- Staining of formalin-fixed tissues requires heating sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 minutes at 95°C, followed by cooling at room temperature for 20 minutes.
Target Information
Thymidylate Synthase (TS) catalyzes the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), essential for DNA biosynthesis.
TS is a critical target for fluoropyrimidines, a major class of antineoplastic drugs used in solid tumor treatment.
In tumor cells, 5-FU and fluorodeoxyuridine are converted to FdUMP, which inactivates TS by forming a ternary covalent complex with the folate cofactor 5,10-methylenetetrahydrofolate.
TS protein expression correlates with response to 5-fluorouracil (5-FU) in colorectal, gastric, head and neck, and breast carcinomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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