Thermo Fisher Scientific Beta-2-adaptin Polyclonal Antibody
Rabbit polyclonal antibody targeting human Beta-2-adaptin. Validated for WB and IP applications. Supplied as a liquid, unconjugated form at 1 mg/mL concentration. Recommended storage at 4°C. Predicted cross-reactivity with Rat and Bovine.
- 카탈로그번호
- A304719Ax (2개 옵션)
- 판매단위
- pk
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunoprecipitation (IP) | 2–10 µg/mg lysate |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 575 to 625 of human Beta-2-adaptin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Rat and Bovine
Target Information
Clathrin-mediated endocytosis is the pathway by which many receptors for nutrients and hormones are internalized to be recycled or down-regulated. During formation of clathrin-coated membranes, clathrin co-assembles with heterotetrameric molecules known as assembly polypeptides (APs) or adaptors, which form a layer of protein coat between the clathrin lattice and the membrane.
There are two characterized adaptors, AP1 and AP2. AP1 is associated with clathrin-coated vesicles at the trans-Golgi network, and AP2 is associated with endocytic clathrin-coated vesicles at the plasma membrane. AP2 specifically interacts with Shc and EGF receptor.
AP2 is composed of four subunits: two ~100 kDa gene products (alpha and beta adaptin) and ~50 and ~17 kDa subunits. There are two alpha-adaptin genes, alpha A and alpha C, which exhibit tissue-specific expression patterns.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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