Thermo Fisher Scientific Beta-2-adaptin Polyclonal Antibody
Beta-2-adaptin 단백질을 표적하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 Immunoprecipitation에 적합. 인간, 랫, 소에서 반응 예측. 액상 형태로 4°C 보관, 1년의 권장 유효기간.
- 카탈로그번호
- A304718Ax (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Beta-2-adaptin Polyclonal Antibody
Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–10 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 575 to 625 of human Beta-2-adaptin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, predicted to react with Rat and Bovine
Target Information
Clathrin-mediated endocytosis is the pathway by which many receptors for nutrients and hormones are internalized to be recycled or down-regulated. During formation of clathrin-coated membranes, clathrin co-assembles with heterotetrameric molecules known as assembly polypeptides (APs) or adaptors, which form a protein coat layer between the clathrin lattice and the membrane.
There are two characterized adaptors, AP1 and AP2:
- AP1: associated with clathrin-coated vesicles at the trans-Golgi network
- AP2: associated with endocytic clathrin-coated vesicles at the plasma membrane and interacts with Shc and EGF receptor
AP2 is composed of four subunits: two ~100 kDa gene products (alpha and beta adaptin) and ~50 kDa, ~17 kDa subunits. Two alpha-adaptin genes (alpha A and alpha C) show tissue-specific expression patterns.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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