Thermo Fisher Scientific P-Selectin Recombinant Rabbit Monoclonal Antibody (3H20L10)
Thermo Fisher의 P-Selectin Rabbit Recombinant Monoclonal Antibody (Clone 3H20L10)은 인간 P-Selectin을 타겟으로 하며 WB, ICC/IF, ELISA에 적합합니다. 높은 특이성과 재현성을 제공하며, 동물 유래 성분이 없는 포뮬레이션으로 안정적인 장기 보관이 가능합니다.
- 카탈로그번호
- 701257
- 판매단위
- pk
카탈로그
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:5,000 | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 | View 1 publication |
| ELISA | Assay-dependent | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 3H20L10 |
| Immunogen | Peptide corresponding to amino acids 113–126 of human P-selectin |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2532443 |
Product Specific Information
- Predicted to react with mouse, rat, and non-human primate based on sequence homology.
- Intact IgG appears on a non-reducing gel as a ~150 kDa band; upon reduction, generates a ~25 kDa light chain and ~50 kDa heavy chain.
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems by cloning specific antibody DNA sequences from immunoreactive rabbits.
- Advantages include:
- Superior specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity due to larger rabbit immune repertoire
Target Information
P-selectin (Selectin P, GMP-140, LECAM3, CD62 antigen-like family member) is a 140 kDa type I transmembrane glycoprotein involved in cell rolling regulation.
It is stored in Weibel-Palade bodies of endothelial cells and α-granules of platelets, and rapidly translocates to the cell surface upon activation by various stimuli (e.g., thrombin, histamine, complement 5a, Ca²⁺ ionophores).
P-selectin mediates interactions between activated endothelial cells or platelets and leukocytes, playing a key role in leukocyte adhesion and inflammation.
It functions as a calcium-dependent receptor binding to sialylated Lewis blood group antigens on neutrophils and monocytes, contributing to processes such as atherogenesis, thrombosis, and tissue destruction.
Clinically, P-selectin is used to distinguish heparin-induced thrombocytopenia with or without thrombosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일: 701257_P-Selectin_CD62P_P16109-1_Rabbit.svg, 701257_P-Selectin_CD62P_P16109-1_Rabbit_PDP.jpeg)
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