Thermo Fisher Scientific P-Selectin Recombinant Rabbit Monoclonal Antibody (3H20L10)

Applications

Product Specifications

Product Specific Information

• Predicted to react with mouse, rat, and non-human primate based on sequence homology.
• Intact IgG appears on a non-reducing gel as a ~150 kDa band; upon reduction, generates a ~25 kDa light chain and ~50 kDa heavy chain.
• Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems by cloning specific antibody DNA sequences from immunoreactive rabbits.
• Advantages include:
  • Superior specificity and sensitivity
  • Lot-to-lot consistency
  • Animal origin-free formulation
  • Broader immunoreactivity due to larger rabbit immune repertoire

Target Information

P-selectin (Selectin P, GMP-140, LECAM3, CD62 antigen-like family member) is a 140 kDa type I transmembrane glycoprotein involved in cell rolling regulation.
It is stored in Weibel-Palade bodies of endothelial cells and α-granules of platelets, and rapidly translocates to the cell surface upon activation by various stimuli (e.g., thrombin, histamine, complement 5a, Ca²⁺ ionophores).
P-selectin mediates interactions between activated endothelial cells or platelets and leukocytes, playing a key role in leukocyte adhesion and inflammation.
It functions as a calcium-dependent receptor binding to sialylated Lewis blood group antigens on neutrophils and monocytes, contributing to processes such as atherogenesis, thrombosis, and tissue destruction.
Clinically, P-selectin is used to distinguish heparin-induced thrombocytopenia with or without thrombosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

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