Thermo Fisher Scientific BFAR Monoclonal Antibody (1C6)
BFAR 단백질을 표적으로 하는 Mouse IgG2a 단일클론 항체로, Western blot 및 ELISA에 적합. 인간 시료 반응성, 비결합형 액상 형태. 세포 사멸 억제 관련 연구용으로 사용. -20°C 보관, 동결/해동 반복 피할 것.
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Thermo Fisher Scientific BFAR Monoclonal Antibody (1C6)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1C6 |
| Immunogen | BFAR (AAH03054, 101 a.a. ~ 200 a.a) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Storage Buffer | Ascites |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
LRFEDIQQNN DIVQSLAAFQ KYGNDQIPLA PNTGRANQQM GGGFFSGVLT ALTGVAVVLL VYHWSSRESE HDLLVHKAVA KWTAEEVVLW LEQLGPWASL
Target Information
The bifunctional apoptosis inhibitor (BFAR) is a scaffold protein that integrates signaling components of the cell’s apoptosis-regulatory machinery.
BFAR is a multidomain protein capable of inhibiting apoptosis induced by TNF-family death receptors (extrinsic pathway) as well as mitochondria-dependent apoptosis (intrinsic pathway).
Interaction of BFAR with Bcl-2 or Bcl-XL via a SAM domain may contribute to its anti-apoptotic properties.
Additionally, BFAR contains a DED-like domain that can suppress apoptosis mediated at the receptor level and is thought to play a role in neuronal survival regulation.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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