Thermo Fisher Scientific TLR7 Monoclonal Antibody (2F6)
TLR7 단백질을 인식하는 Mouse IgG2a 단클론 항체로, Western blot과 ELISA에 적합합니다. 인간 TLR7에 반응하며, 액상 형태로 제공되고 보존제가 포함되어 있지 않습니다. 면역원은 부분 재조합 단백질이며, 친화 크로마토그래피로 정제되었습니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 1 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2F6 |
| Immunogen | TLR7 (NP_057646, 27 a.a. ~126 a.a.) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Protein sequence:
ARWFPKTLPC DVTLDVPKNH VIVDCTDKHL TEIPGGIPTN TTNLTLTINH IPDISPASFH RLDHLVEIDF RCNCVPIPLG SKNNMCIKRL QIKPRSFSGL
Target Information
TLR7 is a highly conserved membrane protein belonging to the Toll-like receptor (TLR) family, containing 27 leucine-rich repeats (LRR) and a TIR domain. It plays a fundamental role in pathogen recognition and activation of innate immunity. TLR7 is activated by single-stranded RNA viruses such as influenza and vesicular stomatitis virus (VSV). It is mainly expressed in lung, placenta, and spleen, and is located near TLR8. Activation of TLR7 via MyD88 and TRAF6 leads to NF-κB activation, cytokine secretion, and inflammatory responses. TLR7 recognizes pathogen-associated molecular patterns (PAMPs) and mediates cytokine production essential for effective immunity.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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