Thermo Fisher Scientific beta Catenin Recombinant Rabbit Monoclonal Antibody (6A3P2)
베타 카테닌 단백질을 인식하는 토끼 유래 재조합 단클론 항체. Western blot, IHC, ICC/IF, ELISA, IP 등 다양한 응용에 적합. 인간, 마우스, 랫트 반응성. 고순도 친화 크로마토그래피 정제. -20°C에서 보관, 연구용 전용.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 | - |
| ELISA | 1 µg/mL | - |
| Immunoprecipitation (IP) | 0.5 µg–4 µg antibody for 400–600 µg extracts | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 6A3P2 |
| Immunogen | Synthetic peptide corresponding to amino acids 1–100 of human beta Catenin (P35222) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2848867 |
Product Specific Information
Immunogen sequence:
MATQADLMEL DMAMEPDRKA AVSHWQQQSY LDSGIHSGAT TTAPSLSGKG NPEEEDVDTS QVLYEWEQGF SQSFTQEQVA DIDGQYAMTR AQRVRAAMFP
Target Information
Beta-catenin is an adherens junction (AJ) protein essential for cell-cell adhesion and epithelial layer maintenance. It interacts with E-cadherin and alpha-catenin to anchor the adhesion complex to the actin cytoskeleton. Beta-catenin also associates with signaling complexes involving adenomatous polyposis coli protein and participates in Wnt/Wingless pathways, influencing morphogenesis and cell proliferation.
Beta-catenin is expressed in various hair follicle cells, basal and peripheral matrix cells, and outer/inner root sheath cells. Dysregulation of beta-catenin is implicated in pilomatrixoma, medulloblastoma, colorectal, ovarian, and other cancers. In the nucleus, it coactivates Lef/Tcf transcription factors that drive expression of proliferation-related genes such as cyclin D and c-myc, linking beta-catenin to tumorigenesis in multiple solid tumors (breast, colon, liver, lung, gastric, prostate, skin).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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