Thermo Fisher Scientific PATZ1 Polyclonal Antibody
PATZ1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF 등 다양한 응용에 적합. 높은 특이성과 재현성을 제공하며, 연구용으로만 사용 가능.
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Thermo Fisher Scientific PATZ1 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 |
Product Specifications
| Specification | Detail |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to amino acids 1–194 of Human PATZ1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.72 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2547952 |
Product Specific Information
- Recommended positive controls: A549, HeLa, HepG2, HCT116
- Predicted reactivity: Mouse (99%), Rat (99%), Rabbit (99%), Bovine (99%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The PATZ1 protein contains an A-T hook DNA binding motif that binds to other DNA binding structures, playing an important role in chromatin modeling and transcription regulation. Its POZ domain functions as a site for protein-protein interaction and is required for transcriptional repression, while zinc-fingers comprise the DNA binding domain.
In small round cell sarcoma, PATZ1 is fused to EWS through an inversion of chromosome 22q, forming a chimeric sequence that includes the transactivation domain of EWS fused to the zinc finger domain of PATZ1. Four alternatively spliced transcript variants have been described for this gene.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일명: PA5-30478_PATZ1_Q9HBE1-1_Rabbit.svg, PA5-30478_PATZ1_Q9HBE1-1_Rabbit_PDP.jpeg)
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