Thermo Fisher Scientific Connexin-26 (GJB2) Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Reconstitution: Add 25 µL, 50 µL, or 0.2 mL of double distilled water (DDW), depending on sample size.
• The antibody ships as a lyophilized powder at room temperature. Upon arrival, store at -20°C.
• Reconstituted solution can be stored at 4°C for up to 1 week. For longer storage, aliquot and keep at -20°C.
• Avoid multiple freeze/thaw cycles.
• Centrifuge all antibody preparations before use (10,000 × g, 5 min).

Target Information

Gap junctions are conduits that allow direct cell-to-cell passage of small cytoplasmic molecules, including ions, metabolic intermediates, and second messengers, thereby mediating intercellular metabolic and electrical communication. Gap junction channels consist of connexin protein subunits encoded by a multigene family. GJBs (gap-junction proteins or connexins) play crucial functional roles associated with these channels.
Defects in GJB3 have been linked to erythrokeratodermia variabilis (EKV), an autosomal dominant genodermatosis characterized by transient red patches or hyperkeratosis.
Mutations in GJB2 have been associated with genetically derived hearing impairments, including autosomal recessive nonsyndromic deafness.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.