Thermo Fisher Scientific NAGA Monoclonal Antibody (OTI6F3), TrueMAB

Thermo Fisher Scientific NAGA Monoclonal Antibody (OTI6F3), TrueMAB

Applications

• Western Blot (WB)

Tested Dilution: 1:2,000
Publications: -

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step.
Recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882).

Target Information

NAGA (N-acetylgalactosaminidase, alpha), also known as alpha-galactosidase B or GALB, is a 411 amino acid lysosomal protein in the glycosyl hydrolase 27 family. It may exist as a homodimer and plays a key role in glycolipid breakdown.
NAGA encodes alpha-N-acetylgalactosaminidase, an enzyme that cleaves alpha-N-acetylgalactosaminyl groups from glycoconjugates.
Located on human chromosome 22q13.2, mutations in NAGA cause Schindler disease (types I, II, III), an autosomal recessive disorder with varying neurological manifestations.
Type I is the most severe, type III has mild-to-moderate effects, and type II (Kanzaki disease) presents with mild intellectual impairment and angiokeratoma corporis diffusum.

For Research Use Only.
Not for use in diagnostic procedures or resale without authorization.