Thermo Fisher Scientific TNFAIP3 Polyclonal Antibody
TNFAIP3(A20) 단백질을 검출하기 위한 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 인간, 마우스, 랫트 반응성. IHC, ICC/IF, ELISA 등 다양한 응용 가능. Protein A로 정제된 고순도 항체로 연구용에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human TNFAIP3, amino acids 51–150 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
TNFAIP3, also known as A20, is located in chromosome band 6q23, a region frequently deleted in B cell lymphomas. It functions as a tumor suppressor gene in Hodgkin lymphoma and various non-Hodgkin lymphoma subtypes.
TNFAIP3 encodes a zinc-finger protein induced by TNF-α, which inhibits NF-κB-dependent gene expression and protects cells from TNF-α cytotoxicity.
Overexpression of TNFAIP3 also inhibits TLR2 and TLR4 mediated interleukin-8 synthesis in airway epithelial cells, acting as a negative regulator of TLR-mediated inflammatory responses, thus preventing excessive immune activation.
At least two isoforms of TNFAIP3 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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